منابع مشابه
Why inflammatory phenotyping is necessary for successful drug evaluation in asthma and COPD.
Identifying and treating the eosinophilic subtype of asthma has now achieved renewed importance for clinicians and scientists involved in clinical trials. This has happened following the near-demise of an antiinterleukin (IL)-5 monoclonal antibody (mepolizumab) as a candidate for asthma treatment [1] and its resurrection in trials based around using induced sputum eosinophils to identify a trea...
متن کاملA Probabilistic Model for COPD Diagnosis and Phenotyping Using Bayesian Networks
Introduction: This research was meant to provide a model for COPD diagnosis and to classify the cases into phenotypes; General COPD, Chronic bronchitis, Emphysema, and the Asthmatic COPD using a Bayesian Network (BN). Methods: The model was constructed through developing the Bayesian Network structure and instantiating the parameters for each of the variables. In order to validate the achiev...
متن کاملPractical phenotyping of difficult asthma.
Department of Respiratory Medicine, University Hospital of North Staffordshire, Stoke-on-Trent, UK Department of Respiratory Medicine, Glenfield Hospital, Leicester, UK North West Lung Centre, University Hospital of South Manchester, Wythenshawe Hospital, Manchester, UK Sheffield Thoracic Institute, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK Division of Therapeutics and Mo...
متن کاملWhy is COPD phenotyping like sorting diamonds?
We can all recognise pure cases of asthma and chronic obstructive pulmonary disease (COPD) by their welldescribed clinical and pathological features. These ‘‘gems’’ are regularly presented as being typical of the disease, with differentiation between asthma and COPD promoted as a key goal of clinical diagnostics [1, 2]. What we have been slow to accept are cases where the differentiation is not...
متن کاملPhenotyping COPD exacerbations using imaging and blood-based biomarkers
Rationale Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are caused by a variety of different etiologic agents. Our aim was to phenotype COPD exacerbations using imaging (chest X-ray [CXR] and computed tomography [CT]) and to determine the possible role of the blood tests (C-reactive protein [CRP], the N-terminal prohormone brain natriuretic peptide [NT-proBNP]) as diagno...
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ژورنال
عنوان ژورنال: Barcelona Respiratory Network
سال: 2016
ISSN: 2385-7110
DOI: 10.23866/brnrev:2016-0030